Levoleucovorin calcium
Khapzory, Levoleucovorin (levoleucovorin calcium) is a small molecule pharmaceutical. Levoleucovorin calcium was first approved as Fusilev on 2008-03-07.
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Brand Name | Status | Last Update |
|---|---|---|
| khapzory | New Drug Application | 2024-12-12 |
| levoleucovorin | ANDA | 2023-08-01 |
| levoleucovorin calcium | ANDA | 2023-08-29 |
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Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Levoleucovorin, Khapzory, Acrotech Biopharma | |||
| 11541012 | 2039-03-25 | DP | |
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1234 clinical trials
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Indications Phases 4
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mucositis | D052016 | EFO_1001898 | — | 2 | — | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | — | — | — | — | 1 |
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Drug
General
| Drug common name | Levoleucovorin calcium |
| INN | calcium levofolinate |
| Description | Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning. It is taken by mouth, injection into a muscle, or injection into a vein.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc(=O)c2c([nH]1)NC[C@H](CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)N2C=O.[Ca+2] |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1908361 |
| ChEBI ID | — |
| PubChem CID | 6006 |
| DrugBank | DB00650 |
| UNII ID | 778XL6VBS8 (ChemIDplus, GSRS) |
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Khapzory – Spectrum Pharmaceuticals
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Fusilev – Spectrum Pharmaceuticals
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4,892 adverse events reported
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